Negative regulation of interleukin-17 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-17 production pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RB, TAGAP, and GNGT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-17 production activity versus CSF2RB in PDAC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CSF2RB →	+0.589	+0.206	<.001	.001	3	5
GBM	TAGAP →	+0.790	+0.187	<.001	<.001	3	5
GBM	GNGT2 →	+0.493	+0.179	.002	<.001	3	5
GBM	SELL →	+0.777	+0.133	.003	<.001	3	5
GBM	LST1 →	+0.683	+0.185	.004	<.001	3	5
OV	EVI2B →	+0.799	+0.136	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032700 vs CSF2RB — PDAC

Explore this scatter interactively →