Negative regulation of interleukin-17 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of interleukin-17 production pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRN, ALCAM, and RAC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRN grouped by Negative regulation of interleukin-17 production-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GRN →	-1.441	-1.380	.001	<.001	3	5
LIVER	ALCAM →	-1.806	-1.500	.009	<.001	3	5
SOFT_TISSUE	RAC1 →	-0.789	-1.425	.002	.004	3	5
BLOOD_Leukemia	ATF4 →	+0.652	+1.346	.006	<.001	2	5
LUNG_SCLC	TAF7L →	+0.513	+0.972	.004	.004	2	5
URINARY_TRACT	PHKB →	+0.876	+1.316	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRN by Negative regulation of interleukin-17 production activity — SOFT_TISSUE

Explore this box plot interactively →