Negative regulation of interleukin-17 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of interleukin-17 production pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC39C, MPRIP, and GNL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-17 production activity versus TTC39C in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TTC39C →	-0.921	-1.063	.003	.006	3	3
BONE	MPRIP →	+1.357	+1.257	.009	.009	3	3
BONE	GNL2 →	-0.636	-1.323	.003	.004	3	3
BONE	TXNDC11 →	+0.573	+1.946	.008	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	SNRPD3 →	-0.794	-1.156	.003	.001	3	2
BREAST	TOMM22 →	-1.393	-1.678	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032700 vs TTC39C — UPPER_AERODIGESTIVE_TRACT

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