Negative regulation of interleukin-13 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-13 production pathway is significantly associated with the RNA expression of multiple genes, with the KIRC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARG2, LEF1, and COX7A2P1, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-13 production activity versus ARG2 in KIRC (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	ARG2 →	+1.486	+0.068	<.001	<.001	3	30
THYM	LEF1 →	+2.864	+0.157	<.001	<.001	3	25
KICH	COX7A2P1 →	+0.893	+0.087	.005	.002	2	20
THYM	LEF1-AS1 →	+1.817	+0.162	<.001	<.001	3	18
LAML	LILRA5 →	+2.895	+0.078	<.001	<.001	3	18
ACC	TNFRSF21 →	+1.631	+0.102	.001	<.001	2	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032696 vs ARG2 — KIRC

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