Negative regulation of interleukin-13 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-13 production pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VIM, PLA2G15, and SAMD4A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-13 production activity versus VIM in PDAC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	VIM →	+0.330	+0.057	<.001	<.001	3	6
LSCC	PLA2G15 →	+0.194	+0.060	.004	.003	3	6
COAD	SAMD4A →	+0.859	+0.102	.006	<.001	3	5
LSCC	AKAP12 →	+0.472	+0.113	<.001	<.001	3	5
GBM	HSP90B1 →	+0.303	+0.081	.001	<.001	3	5
GBM	ITGB1 →	+0.443	+0.113	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032696 vs VIM — PDAC

Explore this scatter interactively →