Negative regulation of interleukin-12 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-12 production pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S351, and ARRB2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-12 production activity versus RCSD1 in LSCC (Pearson r = 0.87).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCSD1 →	+0.711	+0.161	<.001	<.001	3	10
LSCC	RCSD1_S351 →	+0.725	+0.137	<.001	<.001	3	10
GBM	ARRB2 →	+0.393	+0.122	<.001	<.001	3	10
PDAC	RGS19 →	+0.458	+0.061	.001	<.001	3	10
GBM	SAMSN1_S107 →	+0.844	+0.119	<.001	<.001	3	10
LSCC	SAMSN1_S23 →	+0.945	+0.150	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032695 vs RCSD1 — LSCC

Explore this scatter interactively →