Negative regulation of interleukin-10 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-10 production pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S179, and RCSD1_S351, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-10 production activity versus RCSD1 in BRCA (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RCSD1 →	+0.700	+0.084	<.001	<.001	3	10
BRCA	RCSD1_S179 →	+0.932	+0.083	<.001	<.001	3	10
OV	RCSD1_S351 →	+0.907	+0.099	<.001	<.001	3	10
GBM	SASH3 →	+0.583	+0.099	<.001	<.001	3	10
OV	SERPINB9 →	+0.669	+0.071	<.001	<.001	3	10
GBM	SKAP2 →	+0.815	+0.101	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032693 vs RCSD1 — BRCA

Explore this scatter interactively →