Negative regulation of interleukin-10 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of interleukin-10 production pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARPC5, WRN, and ARF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARPC5 grouped by Negative regulation of interleukin-10 production-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ARPC5 →	-1.223	-1.566	.002	.001	3	5
BLOOD_Myeloma	WRN →	+0.790	+1.225	.005	.002	3	5
SKIN	ARF1 →	-0.413	-0.851	<.001	.003	3	4
LUNG_SCLC	MCAM →	-2.623	-1.166	.004	.004	2	5
CNS	HIGD1B →	+0.179	+0.732	.007	.003	2	5
BLOOD_Myeloma	TPST2 →	+1.811	+1.383	.008	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARPC5 by Negative regulation of interleukin-10 production activity — BONE

Explore this box plot interactively →