Negative regulation of interleukin-10 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of interleukin-10 production pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THBS1, VSIR, and TNFRSF21, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-10 production activity versus THBS1 in SKIN (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	THBS1 →	+3.709	+0.287	<.001	<.001	3	11
PANCREAS	VSIR →	+1.923	+0.203	.006	.003	3	8
SKIN	TNFRSF21 →	+2.088	+0.323	<.001	<.001	3	8
URINARY_TRACT	QSOX1 →	+1.830	+0.184	<.001	<.001	3	7
PANCREAS	ANKRD13B →	-1.326	-0.201	.001	<.001	3	7
BREAST	ADGRF1 →	+2.356	+0.143	.001	.006	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032693 vs THBS1 — SKIN

Explore this scatter interactively →