Negative regulation of interleukin-10 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of interleukin-10 production pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF4G2, SNAI1, and KIFC1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF4G2 grouped by Negative regulation of interleukin-10 production-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	EIF4G2 →	+0.605	+1.635	<.001	<.001	3	2
PANCREAS	SNAI1 →	+0.152	+1.691	.008	.004	2	3
LUNG_NSCLC_LUAD	KIFC1 →	-0.140	-1.623	.007	.004	3	2
BLOOD_Leukemia	EPS8 →	+0.380	+2.067	.009	.006	2	3
PANCREAS	LILRB4 →	+0.226	+1.604	.007	.001	3	2
PANCREAS	CRYZ →	+0.162	+2.009	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF4G2 by Negative regulation of interleukin-10 production activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →