Negative regulation of interleukin-10 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of interleukin-10 production pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLN5, KCNN1, and SCARF2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-10 production activity versus CLN5 in LUNG_NSCLC_LUAD (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CLN5 →	+1.460	+1.758	.008	.008	3	2
LUNG_NSCLC_LUAD	KCNN1 →	+0.220	+1.610	.006	<.001	3	2
LUNG_NSCLC_LUAD	SCARF2 →	+3.653	+2.131	<.001	<.001	3	2
OESOPHAGUS	SERPINB1 →	-1.617	-1.631	.006	<.001	3	2
BLOOD_Leukemia	SGSM2 →	+0.659	+1.174	.006	.002	3	2
PANCREAS	DMC1 →	-1.764	-1.787	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032693 vs CLN5 — LUNG_NSCLC_LUAD

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