Negative regulation of interleukin-1 alpha production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-1 alpha production pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6-353P, PGK1P1, and PLLP, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-1 alpha production activity versus RNU6-353P in UCEC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-353P →	+1.643	+0.257	.005	.002	3	2
UCEC	PGK1P1 →	+0.710	+0.223	.004	.001	3	2
LSCC	PLLP →	+0.895	+0.827	.001	.007	3	2
LSCC	PRB2 →	-0.537	-0.674	.006	.001	3	2
LSCC	NR6A1 →	+0.551	+0.693	.002	<.001	3	2
LSCC	GREM1 →	-1.333	-0.901	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032690 vs RNU6-353P — UCEC

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