Negative regulation of interleukin-1 alpha production

Across TCGA cell cohorts, RNA activity of the Negative regulation of interleukin-1 alpha production pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are KIN001-270, BIX02189, and Ispinesib Mesylate, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIN001-270 grouped by Negative regulation of interleukin-1 alpha production-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KIN001-270 →	+0.388	+1.489	.016	.012	3	6
OVARY	BIX02189 →	+0.452	+1.249	.002	.005	3	6
SKIN	Ispinesib Mesylate →	+0.757	+1.182	.002	.006	3	6
SOFT_TISSUE	Niraparib →	+0.975	+2.071	.017	.009	2	6
SOFT_TISSUE	Zoledronate →	+0.799	+2.516	.014	.006	3	5
OVARY	LMB_AB1 →	+0.532	+1.979	.031	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIN001-270 by Negative regulation of interleukin-1 alpha production activity — LUNG_SCLC

Explore this box plot interactively →