Negative regulation of interferon-beta production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interferon-beta production pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN1_S206, WAS, and CORO1A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interferon-beta production activity versus SEPTIN1_S206 in GBM (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN1_S206 →	+0.701	+0.039	<.001	.002	3	9
GBM	WAS →	+0.490	+0.062	<.001	<.001	3	9
LSCC	CORO1A →	+0.582	+0.062	<.001	<.001	3	9
LSCC	FNBP1 →	+0.438	+0.071	<.001	<.001	3	9
LSCC	IL16 →	+0.528	+0.073	<.001	<.001	3	9
UCEC	ANKRD44 →	+0.379	+0.072	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032688 vs SEPTIN1_S206 — GBM

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