Negative regulation of interferon-beta production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interferon-beta production pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLD4, CD72, and LINC02372, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interferon-beta production activity versus PLD4 in OV (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PLD4 →	+0.788	+0.161	<.001	.001	3	5
LSCC	CD72 →	+0.569	+0.204	.002	.007	3	4
GBM	LINC02372 →	+0.014	+0.258	.002	.003	3	3
OV	ABCA8 →	+0.788	+0.133	.006	.007	3	3
OV	PKN2 →	+0.346	+0.136	.003	.002	3	3
LUAD	CRTAM →	+0.525	+0.195	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032688 vs PLD4 — OV

Explore this scatter interactively →