Negative regulation of interferon-beta production

Across TCGA cell cohorts, RNA activity of the Negative regulation of interferon-beta production pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYB561A3, VPS52, and DTNA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYB561A3 grouped by Negative regulation of interferon-beta production-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CYB561A3 →	+1.035	+0.853	<.001	.001	3	4
LARGE_INTESTINE	VPS52 →	+0.787	+0.946	.001	.007	3	3
BLOOD_Leukemia	DTNA →	+2.361	+1.393	.001	<.001	3	3
STOMACH	RRP12 →	+1.320	+0.545	.002	.003	2	4
UPPER_AERODIGESTIVE_TRACT	PPP2R5C →	-0.873	-0.251	.001	.002	3	3
LUNG_SCLC	SLC7A2 →	+2.111	+0.905	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYB561A3 by Negative regulation of interferon-beta production activity — SKIN

Explore this box plot interactively →