Negative regulation of interferon-beta production

Across TCGA cell cohorts, RNA activity of the Negative regulation of interferon-beta production pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFH, PYCARD, and SIRPA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interferon-beta production activity versus CFH in BLOOD_Leukemia (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CFH →	-1.724	-0.708	.004	.005	3	5
BLOOD_Leukemia	PYCARD →	+2.473	+1.341	<.001	<.001	3	5
BLOOD_Leukemia	SIRPA →	+2.310	+0.928	<.001	<.001	3	5
SKIN	BRMS1L →	-0.656	-1.226	.002	.001	3	4
BLOOD_Leukemia	KIAA0930 →	+1.986	+1.084	<.001	<.001	3	4
BLOOD_Leukemia	VPS45 →	-1.109	-1.050	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032688 vs CFH — BLOOD_Leukemia

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