Negative regulation of interferon-alpha production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interferon-alpha production pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK10, GBP4, and LAP3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interferon-alpha production activity versus DOCK10 in HNSC (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DOCK10 →	+0.471	+0.095	<.001	<.001	3	8
UCEC	GBP4 →	+0.603	+0.100	.001	<.001	3	8
UCEC	LAP3 →	+0.750	+0.099	<.001	<.001	3	8
HNSC	LCP2 →	+0.334	+0.068	<.001	<.001	3	8
COAD	UBE2L6 →	+0.533	+0.045	.001	<.001	3	8
UCEC	SAMHD1 →	+0.437	+0.077	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032687 vs DOCK10 — HNSC

Explore this scatter interactively →