Negative regulation of interferon-alpha production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interferon-alpha production pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCL4L2, PDIA3P2, and CYTH4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interferon-alpha production activity versus CCL4L2 in CCRCC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CCL4L2 →	+1.076	+0.262	.008	.006	3	4
LUAD	PDIA3P2 →	-0.630	-0.210	.005	.008	3	3
COAD	CYTH4 →	+0.742	+0.616	<.001	.004	3	3
COAD	AWAT2 →	+0.056	+0.811	<.001	<.001	3	3
COAD	MORF4L1P1 →	+0.729	+0.706	.006	.007	2	4
COAD	ASS1P1 →	+0.699	+0.789	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032687 vs CCL4L2 — CCRCC

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