Negative regulation of interferon-alpha production

Across TCGA cell cohorts, RNA activity of the Negative regulation of interferon-alpha production pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPT, SMIM26, and IMP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAPT grouped by Negative regulation of interferon-alpha production-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MAPT →	-1.226	-0.653	.008	.006	3	4
LUNG_SCLC	SMIM26 →	+0.478	+1.285	.001	.005	2	5
KIDNEY	IMP3 →	-0.530	-1.423	.002	.002	3	3
KIDNEY	SLC44A4 →	+0.228	+1.376	.003	.006	3	3
STOMACH	C1orf116 →	+2.968	+1.286	.004	.001	3	3
STOMACH	MSMO1 →	+1.549	+0.947	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAPT by Negative regulation of interferon-alpha production activity — BREAST

Explore this box plot interactively →