Negative regulation of interferon-alpha production

Across TCGA cell cohorts, RNA activity of the Negative regulation of interferon-alpha production pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NASP, PLCG1, and ZBTB42, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NASP grouped by Negative regulation of interferon-alpha production-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NASP →	-0.207	-1.333	.001	.002	3	5
OVARY	PLCG1 →	-0.141	-0.864	.001	.002	3	4
BLOOD_Leukemia	ZBTB42 →	+0.312	+1.652	.007	<.001	3	4
LUNG_SCLC	GSTO2 →	-0.208	-1.713	.005	.008	3	3
LIVER	CHST2 →	-0.203	-1.912	.003	.005	3	3
LARGE_INTESTINE	CNDP1 →	-0.176	-1.698	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NASP by Negative regulation of interferon-alpha production activity — STOMACH

Explore this box plot interactively →