Interleukin-10 production

pathway activity — cross-omics
GO:0032613Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Interleukin-10 production pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S351, and RENBP, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMRCSD1 →+0.665+0.107<.001<.001310
OVRCSD1_S351 →+0.727+0.041.001<.001310
UCECRENBP →+0.573+0.072<.001<.001310
PDACRGS19 →+0.517+0.051<.001<.001310
GBMRIN3 →+0.469+0.089<.001<.001310
GBMSAMSN1 →+0.720+0.103<.001<.001310
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration