Protein transport into membrane raft

Across TCGA patient cohorts, RNA activity of the Protein transport into membrane raft pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFTN1, RFTN1_S199, and ARHGAP31_S954, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein transport into membrane raft activity versus RFTN1 in LSCC (Pearson r = 0.85).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFTN1 →	+0.605	+0.146	<.001	<.001	3	10
BRCA	RFTN1_S199 →	+0.690	+0.071	<.001	<.001	3	9
LSCC	ARHGAP31_S954 →	+0.652	+0.109	<.001	<.001	3	8
LSCC	CLIC2 →	+0.587	+0.131	<.001	<.001	3	7
LSCC	NOL10 →	-0.389	-0.119	<.001	<.001	3	7
LSCC	GGT5 →	+0.396	+0.100	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032596 vs RFTN1 — LSCC

Explore this scatter interactively →