Protein transport into membrane raft

Across TCGA patient cohorts, RNA activity of the Protein transport into membrane raft pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFTN1, SYNE1, and CD53, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein transport into membrane raft activity versus RFTN1 in OV (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RFTN1 →	+1.101	+0.840	<.001	<.001	3	6
UCEC	SYNE1 →	+1.044	+0.330	<.001	<.001	3	5
LSCC	CD53 →	+0.562	+0.636	.003	<.001	3	5
COAD	INMT →	+0.525	+0.173	.006	.001	3	5
CCRCC	NCF1C →	+0.588	+0.168	.001	.008	3	5
LSCC	BTLA →	+0.410	+0.542	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032596 vs RFTN1 — OV

Explore this scatter interactively →