Protein transport into membrane raft

Across TCGA cell cohorts, RNA activity of the Protein transport into membrane raft pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BANP, CMC2, and ANKRD36, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BANP grouped by Protein transport into membrane raft-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BANP →	+0.828	+1.590	.003	<.001	3	4
BONE	CMC2 →	+1.549	+2.213	.006	.003	2	5
UPPER_AERODIGESTIVE_TRACT	ANKRD36 →	+1.366	+1.873	.002	<.001	3	4
LUNG_NSCLC_LUAD	KLHL29 →	+1.854	+1.473	<.001	<.001	3	4
LUNG_NSCLC_LUSC	METRNL →	-2.015	-1.171	.003	.001	3	4
LUNG_SCLC	N4BP1 →	+0.954	+1.314	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BANP by Protein transport into membrane raft activity — LUNG_SCLC

Explore this box plot interactively →