Response to vitamin K

Across TCGA patient cohorts, RNA activity of the Response to vitamin K pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, TAGLN, and TPM2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to vitamin K activity versus RSU1 in BRCA (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RSU1 →	+0.437	+0.089	<.001	<.001	3	9
CCRCC	TAGLN →	+0.993	+0.179	<.001	<.001	3	9
UCEC	TPM2 →	+1.107	+0.129	.003	.001	3	9
BRCA	ACTN1 →	+0.538	+0.087	<.001	<.001	3	9
BRCA	CAVIN1 →	+0.777	+0.088	<.001	<.001	3	9
BRCA	AEBP1 →	+0.782	+0.086	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032571 vs RSU1 — BRCA

Explore this scatter interactively →