Response to vitamin K

Across TCGA patient cohorts, RNA activity of the Response to vitamin K pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM200B, CYP1B1, and ACTA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to vitamin K activity versus TMEM200B in COAD (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TMEM200B →	+0.784	+0.271	.002	.003	3	5
COAD	CYP1B1 →	+2.017	+0.256	<.001	<.001	3	5
COAD	ACTA2 →	+1.665	+0.301	<.001	<.001	3	5
COAD	LY6H →	+0.461	+0.220	.006	.006	3	5
PDAC	BEST1 →	+0.255	+0.186	.007	<.001	3	5
PDAC	PTGIR →	+0.456	+0.200	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032571 vs TMEM200B — COAD

Explore this scatter interactively →