Response to vitamin K

Across TCGA cell cohorts, RNA activity of the Response to vitamin K pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAB1, RNF141, and PPP1R12A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DAB1 grouped by Response to vitamin K-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DAB1 →	-0.450	-1.742	.001	.001	3	5
BONE	RNF141 →	-0.521	-1.963	.002	<.001	3	5
CNS	PPP1R12A →	+0.299	+0.895	.005	.002	3	5
OVARY	PPP4C →	-0.326	-0.978	<.001	.001	3	5
SKIN	QKI →	+0.169	+1.021	.003	.004	3	4
BONE	MAX →	-0.495	-1.882	.003	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DAB1 by Response to vitamin K activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →