Response to progesterone

Across TCGA patient cohorts, RNA activity of the Response to progesterone pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAP, ZYX_S344, and DPYD, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to progesterone activity versus FAP in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FAP →	+0.836	+0.050	<.001	<.001	3	9
LUAD	ZYX_S344 →	+0.537	+0.059	<.001	<.001	3	8
GBM	DPYD →	+0.767	+0.076	.001	<.001	3	8
OV	C1R →	+0.689	+0.054	<.001	<.001	3	8
OV	C1S →	+0.746	+0.059	<.001	<.001	3	8
COAD	CFH →	+0.647	+0.056	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032570 vs FAP — OV

Explore this scatter interactively →