Response to progesterone

Across TCGA patient cohorts, RNA activity of the Response to progesterone pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESR1, IRAG2, and PSMC1P1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to progesterone activity versus ESR1 in BRCA (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ESR1 →	-2.018	-0.124	<.001	.002	3	5
HNSC	IRAG2 →	-0.925	-0.212	<.001	.002	3	5
LSCC	PSMC1P1 →	+0.185	+0.106	.005	.002	3	4
BRCA	CMAS →	+0.450	+0.176	.009	.004	3	4
BRCA	CYSLTR1 →	-0.969	-0.251	<.001	<.001	3	4
BRCA	ERBB4 →	-1.395	-0.154	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032570 vs ESR1 — BRCA

Explore this scatter interactively →