Response to progesterone

Across TCGA cell cohorts, RNA activity of the Response to progesterone pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYMPK, RAB5A, and RAD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SYMPK grouped by Response to progesterone-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SYMPK →	-0.332	-0.627	.002	.003	3	4
LARGE_INTESTINE	RAB5A →	+0.151	+0.635	.005	.006	3	4
CNS	RAD1 →	-0.336	-0.221	.002	.008	3	3
CNS	RABGEF1 →	+0.142	+0.213	.001	.003	3	3
CNS	MPPE1 →	-0.383	-0.303	<.001	.007	3	3
LUNG_SCLC	STK17B →	+0.149	+0.248	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SYMPK by Response to progesterone activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →