Regulation of cell projection size

Across TCGA patient cohorts, RNA activity of the Regulation of cell projection size pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLS1, HOOK1, and PLEKHG3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell projection size activity versus PLS1 in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PLS1 →	+0.792	+0.094	<.001	<.001	3	10
GBM	HOOK1 →	+0.669	+0.068	<.001	<.001	3	7
GBM	PLEKHG3 →	+0.318	+0.068	.005	<.001	3	6
UCEC	TBC1D2B →	-0.277	-0.078	.002	.002	3	6
CCRCC	HEATR5B →	+0.124	+0.096	<.001	<.001	3	6
CCRCC	STAP2 →	+0.221	+0.091	.008	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032536 vs PLS1 — OV

Explore this scatter interactively →