Regulation of cell projection size

Across TCGA patient cohorts, RNA activity of the Regulation of cell projection size pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COBL, GAL3ST1, and LZTS3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell projection size activity versus COBL in CCRCC (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	COBL →	+1.066	+0.488	<.001	<.001	3	4
CCRCC	GAL3ST1 →	+1.088	+0.405	<.001	<.001	3	4
CCRCC	LZTS3 →	+0.621	+0.284	<.001	.001	3	4
GBM	FAM201A →	+0.642	+1.045	<.001	<.001	3	4
GBM	LILRA4 →	+1.091	+1.074	<.001	<.001	3	4
BRCA	HNRNPA3P13 →	-0.092	-0.333	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032536 vs COBL — CCRCC

Explore this scatter interactively →