Regulation of cell projection size

Across TCGA cell cohorts, RNA activity of the Regulation of cell projection size pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BBS9, PCGF2, and CMPK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell projection size activity versus BBS9 in BLOOD_Myeloma (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	BBS9 →	-1.039	-0.267	.002	.005	3	5
BLOOD_Leukemia	PCGF2 →	-1.620	-0.201	<.001	<.001	3	5
LUNG_NSCLC_LUSC	CMPK1 →	+1.215	+0.338	.008	.001	3	5
BLOOD_Leukemia	ABR →	+1.591	+0.191	.002	.003	3	5
BLOOD_Leukemia	RIPK3 →	+1.980	+0.245	<.001	<.001	3	5
SKIN	GLYCTK →	+0.588	+0.339	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032536 vs BBS9 — BLOOD_Myeloma

Explore this scatter interactively →