Regulation of cell projection size

Across TCGA cell cohorts, RNA activity of the Regulation of cell projection size pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PDCD6IP, CHMP2B, and ARPC3, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell projection size activity versus PDCD6IP in URINARY_TRACT (Pearson r = 0.79).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PDCD6IP →	+1.497	+0.381	.003	<.001	3	14
OESOPHAGUS	CHMP2B →	+1.757	+0.239	<.001	<.001	3	12
OESOPHAGUS	ARPC3 →	+1.144	+0.392	<.001	<.001	3	12
STOMACH	YWHAH →	+1.131	+0.362	<.001	.002	3	11
URINARY_TRACT	CAPNS1 →	+2.208	+0.382	.003	.008	3	11
URINARY_TRACT	OSTF1 →	+2.102	+0.413	.006	.007	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032536 vs PDCD6IP — URINARY_TRACT

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