Regulation of microvillus assembly

Across TCGA patient cohorts, RNA activity of the Regulation of microvillus assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAP1GAP, LY96, and TLR6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microvillus assembly activity versus RAP1GAP in LUAD (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RAP1GAP →	+1.459	+0.397	<.001	<.001	3	7
CCRCC	LY96 →	-0.796	-0.628	<.001	.002	3	6
CCRCC	TLR6 →	-0.524	-0.646	.005	<.001	3	5
CCRCC	GPR141 →	-0.556	-0.728	.002	<.001	3	5
LUAD	TNFSF4 →	-0.658	-0.259	<.001	<.001	3	4
PDAC	CKAP4 →	-0.364	-0.520	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032534 vs RAP1GAP — LUAD

Explore this scatter interactively →