Regulation of microvillus assembly

Across TCGA cell cohorts, RNA activity of the Regulation of microvillus assembly pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX6, BMP7, and ESAM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDX6 grouped by Regulation of microvillus assembly-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DDX6 →	+1.004	+1.729	.001	<.001	3	4
PANCREAS	BMP7 →	-2.486	-1.199	.002	.003	3	4
PANCREAS	ESAM →	+2.596	+1.234	<.001	<.001	3	4
CNS	PPP2R3C →	+0.584	+1.187	<.001	<.001	3	4
LUNG_SCLC	TPI1 →	+1.683	+1.577	.001	<.001	3	4
SKIN	ONECUT2 →	-0.794	-1.162	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDX6 by Regulation of microvillus assembly activity — BONE

Explore this box plot interactively →