Regulation of microvillus assembly

Across TCGA cell cohorts, RNA activity of the Regulation of microvillus assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS18, STK40, and ACTR5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS18 grouped by Regulation of microvillus assembly-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RPS18 →	-0.246	-1.231	.005	.004	3	4
LIVER	STK40 →	-0.252	-1.602	.002	<.001	3	4
BREAST	ACTR5 →	+0.245	+1.082	.003	.003	3	3
SKIN	METTL21C →	-0.262	-1.102	.007	.007	3	3
BLOOD_Lymphoma	LAMP1 →	-0.190	-1.368	.001	.001	2	4
LIVER	TMEM30A →	-0.180	-1.602	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS18 by Regulation of microvillus assembly activity — SKIN

Explore this box plot interactively →