Regulation of microvillus assembly

Across TCGA cell cohorts, RNA activity of the Regulation of microvillus assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FSCN1, PODXL, and KLHL21, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microvillus assembly activity versus FSCN1 in BLOOD_Lymphoma (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FSCN1 →	+5.536	+0.867	<.001	.003	2	11
SKIN	PODXL →	+2.445	+1.563	.003	<.001	3	9
LARGE_INTESTINE	KLHL21 →	+1.011	+1.125	.003	.006	3	6
BREAST	FHL3 →	+1.727	+1.335	<.001	<.001	3	6
BLOOD_Lymphoma	IL15RA →	+2.850	+0.961	.004	.007	3	6
SKIN	TGFB1 →	+1.883	+1.295	.007	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032534 vs FSCN1 — BLOOD_Lymphoma

Explore this scatter interactively →