Regulation of microvillus length

Across TCGA patient cohorts, RNA activity of the Regulation of microvillus length pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLS1, RBM47, and SP100_S410, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microvillus length activity versus PLS1 in BRCA (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLS1 →	+0.601	+0.079	<.001	<.001	3	8
GBM	RBM47 →	+0.375	+0.058	<.001	.002	3	6
LUAD	SP100_S410 →	+0.413	+0.061	.006	.002	3	5
GBM	TEP1 →	+0.282	+0.068	.001	.004	3	5
PDAC	BSPRY →	+0.506	+0.133	<.001	<.001	3	5
LUAD	CRACDL_S490 →	+0.735	+0.109	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032532 vs PLS1 — BRCA

Explore this scatter interactively →