Regulation of microvillus length

Across TCGA cell cohorts, RNA activity of the Regulation of microvillus length pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EREG, CNST, and CCT4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EREG grouped by Regulation of microvillus length-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EREG →	+2.443	+0.896	.008	.002	3	4
OESOPHAGUS	CNST →	-0.693	-1.080	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CCT4 →	+1.471	+1.350	.001	.001	3	4
PANCREAS	NRSN2 →	+2.658	+1.630	<.001	<.001	3	4
STOMACH	MCCC1 →	-0.871	-1.331	.004	.001	3	4
BREAST	ZBED6CL →	-1.021	-0.824	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EREG by Regulation of microvillus length activity — OESOPHAGUS

Explore this box plot interactively →