Regulation of microvillus length

Across TCGA cell cohorts, RNA activity of the Regulation of microvillus length pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCGF2, ABR, and ATP8B2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microvillus length activity versus PCGF2 in BLOOD_Leukemia (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PCGF2 →	-1.620	-0.201	<.001	<.001	3	5
BLOOD_Leukemia	ABR →	+1.591	+0.191	.002	.003	3	5
OESOPHAGUS	ATP8B2 →	-1.926	-0.255	.003	.005	3	5
LUNG_NSCLC_LUSC	CMPK1 →	+1.215	+0.338	.008	.001	3	5
SKIN	GLYCTK →	+0.588	+0.339	.003	<.001	3	5
BLOOD_Myeloma	BBS9 →	-1.039	-0.267	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032532 vs PCGF2 — BLOOD_Leukemia

Explore this scatter interactively →