Regulation of microvillus organization

Across TCGA cell cohorts, RNA activity of the Regulation of microvillus organization pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VIL1, EZR, and WHRN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VIL1 grouped by Regulation of microvillus organization-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	VIL1 →	-0.266	-1.299	.006	.002	2	9
PANCREAS	EZR →	-0.379	-1.622	<.001	<.001	3	8
LUNG_NSCLC_LUSC	WHRN →	-0.362	-1.227	.003	.002	3	5
CNS	H2AC8 →	-0.206	-0.857	.002	.008	3	5
BLOOD_Lymphoma	CYP2C8 →	-0.286	-2.023	.002	.001	3	5
OVARY	SERPINB5 →	-0.135	-1.102	.008	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VIL1 by Regulation of microvillus organization activity — CNS

Explore this box plot interactively →