Regulation of microvillus organization

Across TCGA cell cohorts, RNA activity of the Regulation of microvillus organization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FSCN1, PODXL, and SERPINB8, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microvillus organization activity versus FSCN1 in BREAST (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FSCN1 →	+2.260	+0.258	.001	<.001	3	10
LUNG_NSCLC_LUSC	PODXL →	+3.505	+0.547	.005	.001	2	10
BLOOD_Leukemia	SERPINB8 →	+2.087	+0.188	.004	.008	3	6
LIVER	PHC2 →	+1.110	+0.370	.006	.001	3	5
BREAST	PPP1R18 →	+1.221	+0.275	<.001	<.001	3	5
LUNG_NSCLC_LUAD	HRH1 →	+1.315	+0.283	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032530 vs FSCN1 — BREAST

Explore this scatter interactively →