Microvillus organization

Across TCGA cell cohorts, RNA activity of the Microvillus organization pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLS, GDPD5, and AQP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microvillus organization activity versus GLS in LARGE_INTESTINE (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GLS →	+1.287	+0.254	<.001	.002	2	3
LARGE_INTESTINE	GDPD5 →	+2.232	+0.254	.001	.002	3	2
LARGE_INTESTINE	AQP1 →	-1.702	-0.254	<.001	.002	3	2
LARGE_INTESTINE	SLC22A18AS →	-1.777	-0.254	<.001	.002	3	2
LUNG_SCLC	C10orf90 →	+0.098	+0.240	<.001	.007	3	2
LUNG_SCLC	KLHDC7A →	+2.820	+0.240	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032528 vs GLS — LARGE_INTESTINE

Explore this scatter interactively →