Protein exit from endoplasmic reticulum

Across TCGA patient cohorts, RNA activity of the Protein exit from endoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the KIRP cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XPC-AS1, FNBP4, and NKTR, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein exit from endoplasmic reticulum activity versus XPC-AS1 in KIRP (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	XPC-AS1 →	+0.680	+0.036	<.001	<.001	3	30
UVM	FNBP4 →	+1.537	+0.048	<.001	<.001	3	29
UVM	NKTR →	+1.544	+0.049	<.001	<.001	3	29
UVM	CREBZF →	+1.833	+0.051	<.001	<.001	3	29
THYM	CCDC39 →	+0.802	+0.040	<.001	<.001	3	29
UVM	ATM →	+1.639	+0.050	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032527 vs XPC-AS1 — KIRP

Explore this scatter interactively →