Response to retinoic acid

Across TCGA patient cohorts, RNA activity of the Response to retinoic acid pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IGFBP7, ILK, and STK38L, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to retinoic acid activity versus IGFBP7 in LSCC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IGFBP7 →	+0.585	+0.045	<.001	<.001	3	9
GBM	ILK →	+0.279	+0.031	.005	.007	3	7
CCRCC	STK38L →	+0.221	+0.030	<.001	<.001	3	6
CCRCC	C2 →	+0.383	+0.027	<.001	<.001	3	6
OV	SERPINF1 →	+0.773	+0.031	.001	.001	2	6
OV	COL1A1 →	+0.782	+0.034	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032526 vs IGFBP7 — LSCC

Explore this scatter interactively →