Response to retinoic acid

Across TCGA patient cohorts, RNA activity of the Response to retinoic acid pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAMP, SMO, and SPATA3-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to retinoic acid activity versus HAMP in COAD (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HAMP →	+0.428	+0.204	<.001	<.001	3	3
OV	SMO →	+0.865	+0.204	<.001	<.001	3	3
OV	SPATA3-AS1 →	+0.092	+0.155	.009	.007	3	3
GBM	ACSS3 →	+0.716	+0.125	<.001	.001	3	3
GBM	EVI2A →	-0.410	-0.147	.009	.001	3	3
UCEC	SOCS3 →	+0.845	+0.184	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032526 vs HAMP — COAD

Explore this scatter interactively →