Somite rostral/caudal axis specification

Across TCGA patient cohorts, RNA activity of the Somite rostral/caudal axis specification pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPB41L5, ATOX1, and P4HA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Somite rostral/caudal axis specification activity versus EPB41L5 in GBM (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EPB41L5 →	+0.325	+0.091	<.001	<.001	3	5
PDAC	ATOX1 →	-0.159	-0.076	.005	<.001	3	5
GBM	P4HA2 →	-0.613	-0.066	.002	.008	3	5
LUAD	KIF21A →	+0.342	+0.098	<.001	<.001	3	5
HNSC	FUBP3 →	+0.157	+0.100	.002	<.001	3	4
LUAD	RNH1 →	-0.151	-0.069	.003	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032525 vs EPB41L5 — GBM

Explore this scatter interactively →