Somite rostral/caudal axis specification

Across TCGA cell cohorts, RNA activity of the Somite rostral/caudal axis specification pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRNT1, SNRPD2, and ZNF799, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRNT1 grouped by Somite rostral/caudal axis specification-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRNT1 →	+0.464	+0.180	.006	.005	3	4
SKIN	SNRPD2 →	-0.121	-0.093	.004	.009	3	3
LUNG_SCLC	ZNF799 →	-0.260	-1.296	.001	<.001	3	3
CNS	SLC35B1 →	+0.177	+0.135	<.001	.006	3	3
SOFT_TISSUE	CA6 →	-0.135	-0.163	.006	.007	3	3
UPPER_AERODIGESTIVE_TRACT	COG5 →	+0.312	+0.259	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRNT1 by Somite rostral/caudal axis specification activity — LARGE_INTESTINE

Explore this box plot interactively →